aortic stiffness treatment

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Freiberg MS, Chang CC, Kuller LH, Skanderson M, Lowy E, Kraemer KL, Butt AA, Bidwell Goetz M, Leaf D, Oursler KA, et al. Statistical analysis was performed using SPSS v.24 (IBM Chicago, IL), and for graphical representation, we used GraphPad Prism version 6.0 (Graph Pad Software, San Diego, California, USA). Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. It is difficult for doctors to offer patients an overall assessment of health. We recruited 102 participants; 51 treatment-naïve individuals living with HIV(+) and 51 HIV (−) participants. 2013;3(1):26–30. They include open heart surgery to replace the defective valve, a transcatheter aortic valve replacement (TAVR) to replace the valve, or … 2001;103(1):108–12. Treatment of aortic stiffness as it relates to hypertension. Safar ME, Blacher J, Pannier B, Guerin AP, Marchais SJ, Guyonvarc’h P-M, London GM. In addition, lab tests and medical interrogation were performed to rule out metabolic alterations (e.g. Migraine: A connection to cardiovascular disease? PLoS One. Because aortic stiffness depends on the prevailing blood pressure, effective antihypertensive treatment is expected to reduce it in proportion to the blood pressure reduction. Please note: If you have a promotional code you'll be prompted to enter it prior to confirming your order. Eira M, Bensenor IM, Dorea EL, Cunha RS, Mill JG, Lotufo PA. Most current guidelines recommend treatment based on arbitrary thresholds or the risk of a future event. Several pharmacologic interventions have been developed to slow the progression of aortic stiffness … HIV infection is associated with the spontaneous production of interleukin-1 (IL-1) in vivo and with an abnormal release of IL-1 alpha in vitro. 2012;9(1):26. We calculated the sample size to detect a 0.8 m/s difference and standard deviation of 1.01 m/s, which resulted in 35 individuals in each group, at an alpha of 0.05 and a power of 90%. The power calculation was performed using GPower 3.1.9.2 [35].. A two-sided p-value of < 0.05 was considered significant. Maloberti A, Giannattasio C, Dozio D, Betelli M, Villa P, Nava S, Cesana F, Facchetti R, Giupponi L, Castagna F, et al. Conclusions— Aortic stiffness is increased in HIV-positive individuals receiving antiretroviral therapy including a protease inhibitor. Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Kontush A, Chapman MJ. DAC-Z, CR-B, and GAA-S performed the vascular assessments. Moreover, aortic stiffness is associated with coronary artery disease [13, 14]; and it is an independent predictor of coronary events [15]. Lipid-lowering treatment with statins has shown to reduce aortic stiffness in high-risk patients (9,12), and small clinical trials have indicated a beneficial effect of weight loss as well as exercise training on … Valve replacement is the main treatment for aortic stenosis. J Acquir Immune Defic Syndr. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'. The vasodilation effect on peripheral reflection sites (e.g., arterial bifurcations) might cause a decreased reflection of the backward wave and a reduced contribution to cSBP [60]. Arterial stiffness, also known as atherosclerosis, is a progressive condition that adversely affects arterial function. P9.11 ARTERIAL STIFFNESS … Chow FC, Regan S, Feske S, Meigs JB, Grinspoon SK, Triant VA. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Fellay J, Ledergerber B, Bernasconi E, Furrer H, Battegay M, Hirschel B, Vernazza P, Francioli P, Greub G, Flepp M. Prevalence of adverse events associated with potent antiretroviral treatment: Swiss HIV cohort study. Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, Beyer AM. 1996;45(6):742–8. A generalized linear model was used to adjust cfPWV for age, sex, heart rate (HR), MAP, and body mass index (BMI), which affect and could confound PWV values [34]. 2004;109(2):184–9. PubMed Central  This study aimed to explore the relative contribution of aortic stiffness and volume in treatment-induced change of left ventricular mass in dialysis. J Acquir Immune Defic Syndr. Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function. Google Scholar. Article  Lancet. Exp Mol Med. 2005;25(11):2381–5. Abnormal lipid metabolism after HIV infection is common and can be caused by the HIV infection itself, chronic inflammation, and ART (i.e., PI) [61, 62], which could lead to the development of metabolic syndrome (MetS). Your recovery from aortic stenosis treatment depends on the type of procedure and how healthy you were beforehand. Previous results suggest that treatment with tumor necrosis factor (TNF)-α antagonists may reduce the risk of cardiovascular events in patients with RA. Am J Hypertens. Both articles and products will be searched. As a result, the impact of HIV infection per se on arterial function is not clear. Cookies policy. The opening between the left ventricle and the aorta is therefore narrowed (stenosed). Treatment for aortic valve stenosis depends on the severity of your condition, whether you're experiencing signs and symptoms, and if your condition is getting worse. PubMed  2013;74(10):1263–6. [43] found, besides increased cfPWV, lower BMI, and HDL-c in individuals living with HIV without ART. 2001;7(3):169–76. Any treatment for hypertension, particularly in the young, should address concerns regarding subsequent aortic stiffness, systolic hypertension, and the difficulty in controlling systolic blood pressure as the patient ages. Misse D, Esteve P-O, Renneboog B, Vidal M, Cerutti M, St Pierre Y, Yssel H, Parmentier M, Veas F. HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway. Aortic valve disease is a fatal disease with but a single cure. We found a greater cfPWV in treatment-naïve individuals living with HIV compared to controls, which agrees with previous reports in non-treated HIV infection [19, 39, 40]; however, others have reported similar cfPWV compared to controls [31, 41, 42]. The University of Guadalajara ethics committee approved the study and full informed written consent was obtained from all participants. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol. Valve replacement is the main treatment for aortic stenosis. We assessed cfPWV and central hemodynamics in young individuals with recent HIV infection diagnosis and without antiretroviral therapy. PM-A, GAA-S, CR-B, DC-M, LAG-H, JFA-V, ST-S, and EGC-M conceptualized and designed the study methodology. 2006;113(5):657–63. Can I still get a flu shot? Ann Med Health Sci Res. CAS  Between January 2015 and August 2019, individuals living with HIV were enrolled from the “Antiguo Hospital Civil de Guadalajara” in Guadalajara, Mexico. Values are presented as mean and standard deviation (SD) or median and interquartile range (IQR), depending on the data distribution. The authors received no financial support to conduct this study. PubMed  Finally, the effect of antihypertensive treatment and statin on reverse arterial remodelling, beyond BP control, and mortality should be explored in larger prospective studies. The majority of the individuals living with HIV in our study presented HDL-c < 1.04 mmol/L (78.2% vs. 21.8%) and TC < 5.2 mmol/L (60.8% vs. 39.2%) compared to the HIV(−) group, respectively [6]. Atherosclerosis. PubMed  We observed a greater cfPWV (mean difference = 0.5 m/s; p < 0.01) in HIV(+) compared to controls, even after adjusting for heart rate, mean arterial pressure and smoking. For this reason, the objective of this study was to non-invasively assess and compare arterial stiffness and central hemodynamic in non-previously treated (treatment-naïve) individuals living with HIV versus people without HIV. Hypertension. Delemarre F, Stevenhagen A, Kroon FP, Meenhorst P. Reduced toxoplasmastatic activity of monocytes and monocyte-derived macrophages from AIDS patients is mediated via prostaglandin E2. Squillace N, Trabattoni D, Muscatello A, Sabbatini F, Maloberti A, Giannattasio C, Masetti M, Fenizia C, Soria A, Clerici M, et al. CAS  Among hypertensive dialysis patients, this study investigated whether aortic stiffness determines ambulatory BP … The study complied with the Declaration of Helsinki and was approved by the ethics committee of the Hospital Civil Fray Antonio Alcalde. Clin Infect Dis. MAP was calculated as MAP = pDBP + peripheral pulse pressure (pPP)ˑ0.33. 2010;41(10):2163–70. CAS  Google Scholar. To diagnose aortic valve stenosis, your doctor may review your signs and symptoms, discuss your medical history, and conduct a physical examination. Reduce Your Risk of Arterial Stiffness Arterial stiffness occurs when arteries lose youthful suppleness. CAS  GAA-S, RIC-S, KS-R, MA-Z, MR-S, and DAC-Z performed data curation and formal analysis was conducted by GAA-S, PM-A, CR-B, and RIC-S. GAA-S and PM-A drafted the original manuscript. Article  Weiss L, Haeffner-Cavaillon N, Laude M, Gilquin J, Kazatchkine MD. 2015;66(3):698–722. Weber T, Auer J, O’Rourke MF, Kvas E, Lassnig E, Berent R, Eber B. Arterial stiffness, wave reflections, and the risk of coronary artery disease. J Virol. Continuous data were compared using unpaired t-test or Mann-Whitney’s test if normally or not normally distributed, respectively. We examined the effect of intensive multifactorial treatment in general practice on indices of peripheral and central hemodynamics among patients with screen-detected diabetes. Echeverría P, Bonjoch A, Moltó J, Jou A, Puig J, Ornelas A, Pérez-Álvarez N, Clotet B, Negredo E. Pulse wave velocity as index of arterial stiffness in HIV-infected patients compared with a healthy population. Arterial stiffness is associated with elevated blood pressure (BP), but it is unclear whether it also makes hypertension more resistant to treatment. If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. Contribution to characterization of oxidative stress in HIV/AIDS patients. Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites: the insulin resistance atherosclerosis study. In our study, we found a tendency for lower TC, significantly lower HDL-c, and similar TG levels in treatment-naïve HIV compared to uninfected controls. Part of Maloberti et al. Arterioscler Thromb Vasc Biol. Another mechanism that may cause arterial structural changes is through matrix metalloproteinase (MMPs) dysregulation, which can which can degrade the collagen, elastin, laminin, and fibrillin within the arterial wall. 29. Previous findings of the effect of HIV on arterial stiffness have not been consistent. Carlos G. Ramos-Becerra. Cite this article. As things stand now, aortic stenosis is a problem of the valve itself and there is no medicine proven to prevent aortic stenosis or to reverse the valve tightening. Although these endopeptidases were not assessed in our study, this mechanism could partially explain our findings. 2009;52(1):25. The human microcirculation: regulation of flow and beyond. Arterial stiffness occurs as a consequence of biological aging and arteriosclerosis.Inflammation plays a major role in arteriosclerosis development, and consequently it is a major contributor in large arteries stiffening. Arterioscler Thromb Vasc Biol. Arterial stiffness is recognized increasingly as an important component in the determination of cardiovascular risk, particularly in chronic kidney disease and ESRD populations. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp M, Asmar R, Reneman RS, Hoeks AP, Breteler MM. Article  Pharmacol Res. Aim The aim of this study was to evaluate the effect of ivabradine treatment on aortic stiffness by measuring aortic elastic parameters in patients with heart failure (HF) receiving ivabradine treatment. In Western medicine, the association of aging, increased large-arterial stiffness, and systolic hypertension has been recognized for more than a century. Ju SM, Song HY, Lee JA, Lee SJ, Choi SY, Park J. Extracellular HIV-1 tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-κB dependent pathway in human astrocytes. Google Scholar. Am J Geriatr Cardiol. Arterial stiffness is best characterized by measurement of pulse wave velocity (PWV), which is its surrogate marker. Central hemodynamics among patients with human immunodeficiency virus disease and increases oxidative stress impair no reducing. 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